I don't think so. Usually the inlet is on the bottom and the outlet is on the side (and I have it plumbed exactly like it was originally plumbed, just moved to the end of the manifold instead of having it first in series. However, instead of being oriented vertically (so the valve adjustment handle is at the top, the pressure relieve valve is oriented horizontally. I wouldn't think/have thought that mattered. But a new valve is only $33 so it's worth checking what a new one will do.